Never use was defined as a subject who never had a prescription for selective serotonin reuptake inhibitors before index date. Ever use of selective serotonin reuptake inhibitors was defined as a subject who had at least a prescription for selective serotonin reuptake inhibitors before index date. Both cases and controls were matched with sex and age. We randomly selected 19604 subjects aged 20 years and more without hepatocellular carcinoma as the controls.
Methods: Using the database of the Taiwan National Health Insurance Program, we conducted a case-control study to identify 4901 subjects aged 20 years and more with newly diagnosed hepatocellular carcinoma in 2000-2013 as the cases. Objectives: The purpose of the study was to assess the relationship between selective serotonin reuptake inhibitors use and hepatocellular carcinoma in Taiwan. Lai, Shih-Wei Liao, Kuan-Fu Lin, Cheng-Li Lin, Hsien-Feng The use of selective serotonin reuptake inhibitors in pregnancy may increase the risks of low birth weight, preterm birth, fetal death, and seizures.Ĭase-Control Study Examining the Association between Selective Serotonin Reuptake Inhibitors Use and Hepatocellular Carcinoma. The risks of low birth weight (adjusted odds ratio, 1.58 95% CI, 1.19, 2.11), preterm birth (adjusted odds ratio, 1.57 95% CI, 1.28, 1.92), fetal death (adjusted odds ratio, 2.23 95% CI, 1.01, 4.93), and seizures (adjusted odds ratio, 3.87 95% CI, 1.00, 14.99) were increased in infants who were born to mothers who had received selective serotonin reuptake inhibitor therapy.
We carried out a retrospective cohort study of 972 pregnant women who had been given at least 1 selective serotonin reuptake inhibitor prescription in the year before delivery and 3878 pregnant women who did not receive selective serotonin reuptake inhibitors and who were matched by the year of the infant's birth, the type of institute at birth, and the mother's postal code from 1990 to 2000 in the Canadian province of Saskatchewan. The purpose of this study was to assess the safety of the use of selective serotonin reuptake inhibitors in pregnancy.
Wen, Shi Wu Yang, Qiuying Garner, Peter Fraser, William Olatunbosun, Olufemi Nimrod, Carl Walker, Mark Selective serotonin reuptake inhibitors and adverse pregnancy outcomes.